Kings of Leon, Stormzy and Little Mix will be among the artists entertaining festival-goers at Burton Constable Hall on 26 and 27 May 2017.
The venue was selected for its proximity to the City of Culture and it’s stunning rural location just outside the city, a fantastic place for young people to experience a festival.
The US rockers said it was "going to be a great show, can't wait".
Little Mix tweeted: "YAAAAS!!!! We're headlining the #R1BigWeekend in Hull on 28th May. Bring it on! We seriously cannot wait @BBCR1 😝 the girls x"
All 50,000 tickets for the event are free with a large proportion due to be prioritised for Hull postcodes, making it an exciting addition to the 2017 City of Culture festivities for local people.
It is a fantastic scoop for Hull to host Europe’s biggest free ticketed festival, for which previous hosts have included Norwich, Hackney and Exeter.
The full line-up for Big Weekend 2017 will be revealed in the coming weeks, as will details of how to get tickets.
"Listen to Radio 1, and search on your phone, to find out how you could join the young people of Hull enjoying the biggest pop stars, playing the best new music, from the UK and around the world," said Radio 1 Controller, Ben Cooper.
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